| abstract |
The present invention is directed to a water soluble formulation comprising a compound that neutralizes GM-CSF at a concentration of at least about 20 mg/ml, a tonicity adjusting agent, and a buffering agent, wherein the composition is stable. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF under long-term storage. In a preferred aspect, the formulation is for treatment, preferably for the treatment of inflammatory and autoimmune diseases, preferably allergic and psoriasis, as well as arthritis and asthma. In addition, kits comprising the formulations of the invention are also provided. |