| abstract |
The present invention is an anti-MCAM antibody and antigen-binding fragment thereof which is capable of inhibiting the interaction between MCAM and its ligand, i.e., a protein comprising a laminin α-4 chain. These anti-MCAM antibodies and antigen-binding fragments thereof can be used, for example, to treat inflammatory conditions characterized by infiltration of cells expressing MCAM in vivo to an inflamed site. |