| abstract |
The present invention provides a method for producing a high quality and high yield of a thienopyrimidine derivative having a gonadotropin releasing hormone (GnRH) antagonistic action or a salt thereof. The present invention provides a process for the manufacture of a thienopyrimidine derivative which comprises making 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminemethyl-3-( 6-methoxyindole-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or a salt thereof, 1,1'-carbonyldiimidazole or a salt thereof Oxyamine or a salt thereof or the like. |