| abstract |
The chroma compounds and derivatives of formula I are useful inhibitors of TRPM8. The compounds are useful in the treatment of a variety of TRPM8 mediated conditions and conditions, and are useful in the preparation of pharmaceutical and pharmaceutical compositions useful in the treatment of such conditions and conditions. Examples of such conditions include, but are not limited to, migraine and neuropathic pain. The compounds of formula I have the structure: wherein the definitions of such variables are as defined herein. |