| abstract |
The present invention provides a non-aqueous taxane nanoparticle dispersion formulation that does not contain ethanol. The nano dispersion formulation of the specific example of the present invention includes a taxane, an oil, a nonionic surfactant, a nonaqueous solvent, and an organic acid component, wherein the organic acid component is soluble in a nonaqueous solvent and is by weight The nonionic surfactant active dose is equal to or greater than the amount of non-aqueous solvent by weight. A non-aqueous, docetaxel nanodispersion formulation containing no ethanol is also provided. Nanodispersion formulations of specific examples of the invention include European paclitaxel, oils, nonionic surfactants, non-aqueous solvents, and organic acids that are soluble in non-aqueous solvents and substantially free of any conjugate base. Methods of using nanodispersed formulations are also provided, as well as kits including nanodispersed formulations. |