http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-201416437-A

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filingDate 2012-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b83df704eb630a1acc3589f49e0172ec
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publicationDate 2014-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber TW-201416437-A
titleOfInvention Nano electrode wafer
abstract The present invention provides a nanoelectrode wafer that can be applied to locally electroporate a cell membrane of a single cell to allow microfluidic substances to enter a single cell. The nano electrode wafer comprises a ruthenium base layer, a structural layer, an insulating layer and a microfluidic layer. When a single cell is placed on a pore between a plurality of nanoelectrodes that have generated at least one electric field, an electric field acts on a single cell to locally electroporate a cell membrane of a single cell to produce a plurality of nanopore, followed by a microfluidic substance. (eg drugs, DNA molecules, etc.) will flow into a single cell via a small well. The invention not only effectively and precisely controls the size of the pores in the cell membrane, but also clearly provides a path for subsequent optical observations to track the entry of microfluidic substances into a single cell.
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Total number of triples: 29.