| abstract |
The present invention discloses a fused pyrimidine compound having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring, and having a complex substituent at the 2-position of the pyrimidine ring and a substituted amine at the 4-position and An optional aliphatic, functional, and/or aromatic component substituted with the pyrimidine ring and other positions of the A ring. These compounds are inhibitors of the AAA proteasome complex of p97 and are useful agents for the treatment of diseases associated with p97 biological activity, such as cancer. |