| abstract |
An object of the present invention is to provide an efficient production method which can be used in the field of regenerative medicine and surgery, and which can efficiently obtain a large amount of the self-organized peptide derivative described above. The present invention provides a manufacturing method which is a combination of: (i) a convergent sequence construction step using a common unit of an amino acid sequence, and (ii) first separation into 2 sulfate, 4 methanesulfonate or 4 trifluoro After the salt of acetic acid (TFA) salt is exchanged, it is further exchanged to the 4-hydrochloride salt. |