| abstract |
The present invention describes 2,3-benzodiazepines of the general formula (I) having BET protein inhibition, in particular BRD4 inhibition: wherein R1a, R1b, R1c, R2, R3, R4, R5, A and X Having the meanings set forth in the description; intermediates useful in the preparation of such compounds of the invention; pharmaceutical compositions comprising the compounds of the invention; and their use in hyperproliferative disorders, in particular for the prophylaxis of neoplastic disorders and Therapeutic use. BET protein inhibitors are also described for use in benign proliferative, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, neurodegenerative disorders, inflammatory disorders, atherosclerotic disorders and controls Male fertility. |