| abstract |
The present invention provides a monoclonal antibody and a use thereof, which is described in the following (A), and can be specifically combined with mycobacteria, particularly the lipid arabinomannose of Mycobacterium tuberculosis: (A) contains the lower The heavy chain variable region of the heavy chain CDR1 to CDR3 of (a) to (c) and the light chain variable region of the light chain CDR1 to CDR3 containing the following (d) to (f) are joined by a linker. Monoclonal antibody: (a) heavy chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO: 1, (b) heavy chain CDR2 consisting of the amino acid sequence represented by SEQ ID NO: 2, and (c) The heavy chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO: 3, (d) the light chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO: 4, and (e) the amine group represented by SEQ ID NO: The light chain CDR2 consisting of the acid sequence and (f) the light chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO: 6. |