| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bd7a45a343acd10e3f5d8775dda2157 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2013-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a54bd8e297d44f89d1c1e84d00f08c38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4960f7fa7e10c12e1fe177974dc54ee8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16c3e218d7808aa17212050a43b702e1 |
| publicationDate |
2013-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-201350507-A |
| titleOfInvention |
Anti-epithelial cell adhesion molecule (EpCAM) antibody and method of use thereof |
| abstract |
The present invention discloses an isolated monoclonal antibody or antigen-binding fragment thereof. The antibody or antigen-binding fragment has the following characteristics: (a) has a specific binding affinity for an epithelial cell adhesion molecule (EpCAM) comprising an amino acid sequence of SEQ ID NO: 1; (b) a pair can be expressed The cancer cells of EpCAM have specific binding affinity, and the cancer cell line is selected from the group consisting of oral cancer cells, nasopharyngeal cancer cells (NPCs), colorectal cancer cells, and ovarian cancer cells; (c) pairs of humans Human umbilical vein endothelial cells (HUVEC) and normal nasal mucosal epithelia (NNM) do not have binding affinity. The present invention also discloses an isolated monoclonal antibody or antigen-binding fragment thereof which is specific for an epitope in the sequence of KPEGALQNNDGLYDPDCDE (SEQ ID NO: 63) in the EGF-like region II of the epithelial cell adhesion molecule (EpCAM). Sexual binding affinity. The invention also discloses methods of using such methods. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I754504-B |
| priorityDate |
2012-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |