http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-201350500-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_461514df460e0cdd5644e86ba60adbf7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2012-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b258b07bf00f019b3ffd964d3acd9e8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31ccec3140a94b74edbfe8fa8eab0e8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_392b47151cd7f6e296e179e1b93480c9 |
| publicationDate | 2013-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-201350500-A |
| titleOfInvention | Peptide compound for inhibiting platelet aggregation |
| abstract | The present invention provides a peptide compound comprising an amino acid sequence of the formula X2-Trp-X3-X4-X5, X1-X2-Trp-X3-X4-X5 or X1-X2-Trp-X3-X4 or a pharmaceutical thereof An acceptable salt wherein X1 is selected from the group consisting of His(H), Arg(R), Lys(K), Gly(G), Ala(A), Val(V), Leu(L), Ile(I), Ser a group consisting of (S), Thr (T), Cys (C), Asn (N), and Gln (Q); X2 is selected from Lys (K), dLys (dK), Arg (R), Gly ( G), Ala (A), Val (V), Leu (L), Ile (I), Ser (S), Thr (T), Cys (C), Gln (Q), Asn (N), Glu ( a group consisting of E) and Asp (D); X3 is selected from Phe (F), Tyr (Y), Trp (W), Gly (G), Ala (A), Val (V), Leu (L) ), Ile(I), Ser(S), Thr(T), Cys(C), Met(M), Asn(N), Gln(Q), Glu(E), and Asp(D) Group; X4 is selected from Tyr (Y), Gly (G), Ala (A), Val (V), Leu (L), Ile (I), Ser (S), Thr (T), Cys (C) a group consisting of Gln(Q) and Asn(N); X5 is selected from Gly(G), Ala(A), Val(V), Leu(L), Ile(I), Ser(S), A group consisting of Thr(T), Cys(C), Phe(F), Tyr(Y), Trp(W), Met(M), Lys(K), and Arg(R). The invention also provides a pharmaceutical composition comprising a peptide compound of the invention and a pharmaceutically acceptable excipient or carrier. The invention further provides a method of inhibiting platelet aggregation comprising administering to a subject in need of such treatment an effective amount of a peptide compound of the invention or a pharmaceutical composition of the invention. The present invention still further provides a method for preventing or treating a thrombosis-related disease by administering to a subject in need of such treatment an effective amount of the peptide compound or pharmaceutical composition of the present invention. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113429457-A |
| priorityDate | 2012-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 218.