| abstract |
The present invention, in certain embodiments, discloses an immediate release solid oral dosage form comprising a plurality of particles, each particle comprising: (i) a core comprising a first active agent, (ii) comprising a layer laminated to the core a coating of a second active agent, and (iii) an acidic pH sensitive material laminated to the core of the coating, wherein the United States Pharmacopoeia Apparatus 2 (paddle type) is used in 50 ml of 0.1 N HCl at 37 ° C at 50 rpm. The dosage form releases at least about 70% of the second active agent in 45 minutes as measured by an in vitro dissolution test. |