abstract |
The present invention discloses a modular composition comprising: 1) an oligonucleotide; 2) one or more of the four GalNAc ligands of formula (I), which may be the same or different; optionally, 3) one or more Linkers, which may be the same or different; and, as appropriate, 4) one or more targeting ligands, solubilizers, pharmacokinetic enhancers, lipids, and/or masking agents. |