| abstract |
The present invention relates to a guanamine-containing compound of the formula (1); and a salt thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2 and/or Pim-3 protein kinase activity or enzymatic function. In other embodiments, the invention relates to pharmaceutical compositions comprising the compounds disclosed herein; and to their use in the prevention and treatment of Pim kinase-related conditions and diseases, preferably cancers. |