abstract |
The invention belongs to the field of medicine and chemical industry, and relates to a sterol derivative, a preparation method thereof and use thereof. In particular, the invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of -OH, =O, H and C1-C3 alkyl; R2 is selected from - OH, H and C1-C3 alkyl; R3 is selected from -OH, =O, H and C1-C3 alkyl; R4 is selected from -OH, H and C1-C3 alkyl; and R1, R2, R3 and Any 0, 1, 2, 3 or 4 of R4 is -OH. The compound of the present invention is capable of effectively inhibiting HMG-CoA reductase, tumor cells, and lipase, and has potential as a drug for reducing, antitumor, or losing weight. |