| abstract |
An object of the present invention is to provide a bone strengthening agent which promotes proliferation of osteoblasts and also inhibits osteoclast differentiation and bone resorption by osteoclasts, thereby effectively preventing or treating osteoporosis or A variety of bone diseases such as fractures, rheumatism, and arthritis; and products for bone reinforcement such as foods, foods, and medicines containing the bone strengthening agent. The present invention is a bone strengthening agent comprising a whey protein hydrolyzate as an active ingredient. In particular, it has the following characteristics: the molecular weight distribution of the whey protein hydrolyzate is 10 kDa or less, and the main peak is 200 Da to 3 kDa, the APL (average peptide chain length) is 2 to 8, the free amino acid content is 20% or less, and the antigenicity is The antigenicity of β-lactoglobulin is 1/10,000 or less; thereby, it is possible to form a bone strengthening agent which is hypoallergenic and has little bitterness. |