| abstract |
The present invention relates to a bicyclic ring of the following formula, or a pharmaceutically acceptable salt thereof, wherein: X-form-O-, -N(R), -C(R8)(R9) or- C(O)-; and Y is -O-, -N(R), -C(R8)(R9) or -C(O)- and the remaining variables are set forth herein. The compounds of the invention are potent inhibitors of the PAR-1 receptor. The compounds of the invention are useful in the treatment or prevention of conditions such as secondary prevention of ASC, myocardial infarction or stroke or disease states such as PAD. |