| abstract |
The present invention relates to a process for the preparation of travoprostol of the formula (I) which comprises stereoselectively reducing a compound of the formula (II), and the resulting compound of the formula (III), if crystallized if necessary, Reduction of the lactone group of the compound of the formula (III), removal of the p-phenyl-benzylidene protecting group of the compound of the formula (IV) thus obtained, □ the resulting triol of the formula (V), crystallization if necessary After conversion, it is converted to the acid of formula (VI) by Wittig reaction, which is subsequently esterified. |