| abstract |
The inventors of the present invention have an amino acid residue in the variable region sequence of a humanized EP27 antibody which inhibits the proliferation of cancer cells by exerting cytotoxicity and neutralizing activity against cancer cells expressing human anti-human epiregulin (Epireglulin). The base was appropriately substituted, and the anti-epidermal regulator antibody showing cross-reactivity between the non-human animal cynomolgus monkey and the human animal was successfully produced, and the anti-epithelin antibody which was inhibited by chemical decomposition was inhibited by the isoelectric point. The epiregulin antibody, the anti-epimodulin antibody having an increased intermediate temperature at which the thermal modification is increased, and the anti-Epiregulin antibody having a reduced amount of the combination. |