| abstract |
The invention discloses a sterol derivative and a preparation method and application thereof. The sterol derivative includes a sterol compound having the formula (I) or a pharmaceutically acceptable salt thereof, or an extract containing the same, or a composition comprising the same. Wherein, structural formula (I) is as follows: wherein R1 is -OH, =O, H, or C1-C3 alkyl; R2 is -OH, H, or C1-C3 alkyl; R3 is -OH, =O , H, or C1-C3 alkyl; R4 is -OH, H, or C1-C3 alkyl, and at least one of R1, R2, R3, R4 is -OH. The compound of the formula (I) can be used for the preparation of a medicament having an inhibitory effect on HMG-CoA reductase activity, and the prepared medicament can effectively inhibit HMG-CoA reductase activity or be used for preparing an anticancer drug. . |