| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dcc7d7259def30e33dbf2ba33a42672 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-02036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate |
2012-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a90dfe3dd98450570f4e18f5046fb089
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fadcc428baaf94ffc66b10a32216800 |
| publicationDate |
2013-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-201326196-A |
| titleOfInvention |
Modified form of Pseudomonas exotoxin A |
| abstract |
Pseudomonas exotoxin A or "PE" is a 66 kD potent cytotoxic protein secreted by a Pseudomonas aeruginosa bacterium. A variety of types of PE have been coupled to other proteins, such as antibodies, to produce therapeutically useful cytotoxic conjugates that selectively target desired phenotype cells, such as tumor cells. In the present invention, a peptide extending over a sequence of about 38 kD of Pseudomonas exotoxin A protein is analyzed to detect the presence of an immunogenic CD4+ T cell epitope. Six immunogenic T cell epitopes have been identified. Residues within each epitope have been identified by introducing a target amino acid substitution to reduce or prevent the immunogenic T cell response of the PE molecule, which can be administered to a heterologous host. |
| priorityDate |
2011-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |