| abstract |
The present invention relates to an intra-articular injection composition for the treatment or symptomatic improvement of a joint disease, which comprises a hyaluronic acid hydrogel crosslinked with an alkylenediamine. The composition according to the present invention exhibits good biocompatibility, long-term joint analgesic effect by one injection due to excellent in vivo retention, cartilage protective effect, and inhibitory effect on synovitis. As a result, the composition according to the present invention can be effectively used as a therapeutic injection for arthritis. |