| abstract |
The present invention relates to an antibody or antibody fragment capable of binding to a phosphorylcholine and/or a phosphorylcholine conjugate, wherein the antibody or antibody fragment comprises a heavy chain variant (VH) region and/or a light chain variant (VL) region, Wherein the -(a) VH region comprises an amino acid sequence comprising 1, 2 or 3 complementarity determining regions (CDRs) selected from the group consisting of: a CDR1 sequence comprising the same as SEQ ID a sequence of NO: 17 having at least 25%, 50%, 75% or 100% sequence identity amino acid sequence; a CDR2 sequence comprising at least 5%, 11%, 17 having the sequence of SEQ ID NO: 18. %, 23%, 29%, 35%, 47%, 52%, 58%, 64%, 70%, 76%, 82%, 94% or 100% sequence amino acid sequence sequence; and CDR3 sequence, It comprises at least 4%, 9%, 13%, 18%, 22%, 27%, 31%, 36%, 40%, 45%, 50 with the sequence of SEQ ID NO: 19, 20, 21 or 22. %, 54%, 59%, 63%, 68%, 72%, 77%, 81%, 86%, 90%, 95% or 100% sequence identity amino acid sequence; and/or (b) VL The region includes an amino acid sequence comprising 1, 2 or 3 excimers selected from the group consisting of Defining region (CDR): a CDR4 sequence comprising at least 5%, 11%, 17%, 23%, 29%, 35%, 47%, 52%, 58% having the sequence of SEQ ID NO: 23 or 24. , a 64%, 70%, 76%, 82%, 94% or 100% sequence identity amino acid sequence; a CDR5 sequence comprising at least 14%, 28%, 42 having the sequence of SEQ ID NO: Amino acid sequence of %, 57%, 71%, 85% or 100% sequence identity; a CDR6 sequence comprising at least 11%, 22%, 33%, 44% of the sequence of SEQ ID NO: Amino acid sequence of 55%, 66%, 77%, 88% or 100% sequence identity. |