abstract |
The present invention provides a relaxin fusion protein in which a linker links the carboxy terminus of relaxin to a prolonged half-life protein moiety, and the linker comprises a protease cleavage site. Accordingly, the present invention provides a relaxin fusion polypeptide having a half-life extension whereby the fusion protein itself acts to release a depot of biologically active relaxin. Furthermore, the present invention provides a nucleic acid sequence encoding the fusion polypeptide, a vector comprising the nucleic acid sequence, a cell expressing the relaxin fusion polypeptide, a pharmaceutical composition of the fusion polypeptide, and a pharmaceutical use. |