abstract |
The present invention provides a relaxin fusion polypeptide A-L-B having a relaxin A chain and a relaxin B chain non-wild type array, wherein the A chain and the B chain are linked by a linker peptide. The invention further provides relaxin fusion polypeptides having an extended half-life. Furthermore, the present invention provides a nucleic acid sequence encoding the above fusion polypeptide, a vector comprising the same, a pharmaceutical composition of the fusion polypeptide, and a medical use thereof |