| abstract |
The present invention describes a pharmaceutical composition comprising: a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand, wherein the sense strand and the antisense strand are selected from the group consisting of SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165) and SERPINH1_51 (SEQ ID NOS: 101 and 168) oligonucleotides; and a pharmaceutical carrier comprising a mixture of retinoids and lipid vesicles. These pharmaceutical compositions are suitable for enhancing the regulation of HSP47 expression by siRNA. |