abstract |
The present invention discloses a compound of the formula (I) or a prodrug thereof; wherein: R1 is -CH2CF3 or -CH2CH2CF3; R2 is -CH2CF3, -CH2CH2CF3 or -CH2CH2CH2CF3; R3 is H or -CH3; each Ra is independently F, Cl , -CN, -OCH3 and/or -NHCH2CH2OCH3; and z is 0, 1 or 2. Also disclosed are methods of inhibiting the Loch protein (Notch) receptor using such compounds, and pharmaceutical compositions comprising such compounds. These compounds are useful for treating, preventing or slowing the progression of a disease or condition, such as cancer, in a variety of therapeutic areas. |