| abstract |
The invention provides IL-1α binding proteins, including chimeric, CDR-grafted and humanized antibodies that bind to IL-1α. The binding protein of the present invention has high affinity for IL-1α and neutralizes IL-1α activity. The binding protein of the present invention may be a full length antibody or an IL-1α binding portion thereof. The invention also provides methods of making the binding proteins of the invention and methods of using the binding proteins of the invention. The IL-1α binding protein of the present invention is useful for detecting IL-1α and inhibiting IL-1α activity, including in a human subject suffering from a disease or condition that is impaired by IL-1α activity. |