| abstract |
The IL4/IL13 binding protein comprises a binding region that inhibits IL4/IL13 binding to IL4Ralpha and a common plus-chain complex (type 1), and inhibits IL4 binding to IL4Ralpha and IL13Ralpha1 complex (type 2) and IL13 binding to IL13Ralpha1 and / or IL13Ralpha2, which can be used to treat cancer, inflammation and other pathological conditions, such as allergic or fibrotic conditions, especially lung conditions. |