| abstract |
The present invention relates to compounds of formula I, and pharmaceutically acceptable salts, esters and prodrugs thereof, which are JAK kinase inhibitors. The invention also relates to intermediates for the manufacture of such compounds, preparation of the compounds, pharmaceutical compositions containing the compounds, methods of inhibiting JAK kinase activity, methods of inhibiting platelet aggregation, and prevention or treatment of at least in part by JAK kinase activity A method that mediates a wide variety of conditions, such as unwanted thrombosis and Non Hodgkin's Lymphoma. |