abstract |
The invention discloses a method for the preparation of tert-butyl 6-chloro-3, 5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl (4R, 6S)-(6-hydroxymethyl-2, 2-dimethy1-1, 3-dioxan- 4-yl)acetate (BHA), Rosuvastatin and Atorvastatin. |