| abstract |
This invention provides a novel compound having both angiotensin II antagonisim and PPARr activation, and useful as a prophylactic agent and/or treating agent for hypertension, cardiac, atheroscherosis, type 2 diabetes, diabetic complication, metabolic syndrome and the like, and a pharmaceutical composition comprising the compound. This invention is directed to the compound represented by the following general formula (I), salt thereof or solvate thereof, and a pharmaceutical composition comprising the compound. [wherein, ring A represents a pyridine ring, ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring, X represents C-R5 or a nitrogen atom, R1 represents a C1-6 alkyl, R2 represents a C1-6 alkyl or a C3-8 cycloalkyl, R3, R4, R5 each independently represents a hydrogen atom, a halogen atom, a C1-6 alkyl, a halo-C1-6 alkyl or a C1-6 alkoxy which may have substituents.] |