http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-201209058-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_015c27707dd641eb59768a705b23690b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca0c55358dd4093594f096a307037acc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e02fa881b17f88e0cc05f742d2469d78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39d1926949ff15603bafa71df38656f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_902ba55e8728b06647e39933ab4fe1ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee85b08b1523042ae15e0c9f10dcfacb |
| publicationDate | 2012-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-201209058-A |
| titleOfInvention | A novel process for the synthesis of pemetrexed disodium salt |
| abstract | The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 which comprises the step of purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps: a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2. The present invention relates also to a process for the preparation of the disodium salt 5 comprising the above-mentioned process for the preparation of pemetrexed diethyl ester 2. A further subject of the present invention is the crystalline form of pemetrexed diethyl ester 2. |
| priorityDate | 2010-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.