| abstract |
This invention discloses a crosslinked chitosan, wherein the crosslinker comprises a diacid or an anhydride thereof, such as malonic acid, succinic acid, succinic anhydride, glutaric acid, glutaric anhydride, and polylactic acid containing at least two carboxyl groups, and may be substituted by amino group, such as aspartic acid or glutamic acid. In addition, this invention also discloses a method or preparing crosslinked chitosan, wherein the generation of the crosslinking structure is preferably carried out in the presence of carbodiimide and more preferably in the presence of N,N-(3-diaminopropyl)-N'-ethyl-carbodiimide and N-hydroxyl-succimide. |