| abstract |
The present invention provides a compound having BRAF inhibition activity, represented by the following formula (I), or the pharmacologically acceptable salt thereof, [wherein R1 and R2 are, same or different, hydrogen atom, halogen atom, C1-4 alkyl, or halo C1-4 alkyl; R3 is hydroxyl, C2-4 alkynyl(the said C2-4 alkynyl optionally has one hydroxyl or acetoxy as substituent), - NR5aR5b, azetidinyl(the said azetidinyl optionally has one C1-4 alkyl as substituent), oxazolidinyl(the said oxazolidinyl optionally has one oxo as substituent), pyrrolidinyl(the said pyrrolidinyl optionally has one C1-4 alkyl as substituent), dioxanyl, or pyrazolyl; R5a and R5b are, same or different, hydrogen atom, C1-4 alkyl, or hydroxy C1-4 alkyl; R4 is hydrogen or C1-4 alkyl; n is 1 or 2; Y is C-R6 or nitrogen atom; R6 is hydrogen atom or halogen atom]. |