abstract |
The present invention relates to novel fluoro-substituted 3, 5-dicyano-4-(1H-indazol-5-yl)-2, 6-dimethyl-1, 4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders. |