| abstract |
The present invention relates to imidazole derivatives of the general formula wherein R1 signifies halogen, lower alkyl or lower alkoxy; R2 signifies lower alkyl, lower hydroxyalkyl or lower alkoxyalkyl; R3 signifies hydrogen, lower alkyl, lower hydroxyalkyl or alkoxyalkyl; Q signifies either-N= or -CH=; R4 is a group of formula IIa or IIb wherein X, Y and Z independently are -CH= or -N=, and whereby only one of X or Y can be a nitrogen atom; R5 and R6 independently are hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, -(CH2)m-(CO)O-lower alkyl, -(CH2)m-S(O)2-lower alkyl, -(CH2)m-C(O)-NR'R" and where m=0-3 and R'and R" are independently hydrogen or lower alkyl; as well as to pharmaceutically acceptable salts thereof. It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists. They can be used in the treatment or prevention of mGluR5 receptor mediated disorders. |