http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-201100445-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b1c7560aa50b0da1769cd5b6f735b69 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 2010-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d289e9d3419be903a7fbd1e4ad4868b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebcaa2cb4d33525608688271120975ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd1aabfd39fa7ef38a7a19381e0b1e5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79c91fc0027b50032a0c794b8a222778 |
| publicationDate | 2011-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-201100445-A |
| titleOfInvention | Production method of peptide thioesters |
| abstract | The issue of this invention is to provide a novel method for converting a peptide chain into a peptide thioester through a chemical manner. The inventors of this invention focus on the cysteine residue in the peptide chain and then found that: a –C(=X)-R.sub.1 group is introduced into the thiol group of the cysteine residue. A compound reaction having the leaving group represented by –NH-C(=Y)NHR.sub.3 in the organic solvent is performed. Accordingly, the –NH-C(=Y)NHR.sub.3 group is added on the carboxyl group of the N-end peptide bond of the cysteine residue. As a result, the peptide bond is cleaved, and the peptide fragment at the C-end is removed. The invention further found that: with the following so-called thiol exchange reaction: since the thiol is reacted with a peptide chain added with the –NH-C(=Y)NHR.sub.3 group in a buffer solution, the carbonyl carbon bonded with the –NH-C(=Y)NHR.sub.3 group is now bonded with the thiol group having the thiol, and the –NH-C(=Y)NHR.sub.3 group comes off, and the peptide chain is converted into a peptide thioester. |
| priorityDate | 2009-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 174.