| abstract |
The present invention relates to a compound or a pharmaceutically acceptable salt thereof that has excellent ability for glucokinase activation. The provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof: [wherein R1 is the same or different C1-C6 alkyl, C1-C6 halogen-alkyl, C1-C6 alkyl substituted by one or two hydroxyl and the like; R2 is a phenyl optionally substituted by independently 1 to 5 substituets selected from A group, or a pyridyl or pyrazinyl optionally substituted by independently 1 to 3 substituets selected from A group; R3 is an alkyl optionally substituted by independently 1 to 5 substituets selected from B group and the like; U is an oxygen atom or carbonyl; n is an integral of 0 to 3; substituets A group is a halogen atom, C1-C6 alkoxy, C2-C7 alkylcarbonyl, C2-C7 halogen-alkylcarbonyl, C2-C7 alkoxycarbonyl and the like; substituets B group is a halogen atom, C2-C7 alkylcarbonyl, C2-C7 alkoxycarbonyl, carbamoyl and the like.] |