| abstract |
The present invention relates to N-[(6-azabicyclo[3.2.1]oct-1-yl)arylmethyl]benzamide derivatives of general formula (I): - R represents a hydrogen atom or a (C1-C6)alkyl or (C3-C7) cycloalkyl group, optionally substituted with one or more of the following: fluorine, (C3-C7)cycloalkyl, (C2-C4)alkenyl, phenyl, (C1-C6)alkoxy or hydroxy; R1 represents a phenyl or naphtyl, optionally substituted with one or more of the following: halogen, (C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkyl, NR4R5, (C1-C6) alkylthio, (C1-C6)alkyl-SO2, phenyl or heteroaryl; R2 represents one or more hydrogen or halogen atoms, halo(C1-C6)alkyl, (C1-C6) alkyl, (C3-C7)cycloalkyl or (C3-C7)cycloalkyl(C1-C3)alkyl; R3, R4 and R5 represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl group; R6 represents a (C1-C6)alkyl group; R4 and R5 may together form a ring chosen from azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine, piperazine or azepine rings, optionally substituted with a (C1-C6)alkyl group. Therapeutic use and method of synthesis. |