| abstract |
The invention relates to the novel products of formula (I): in which represents a single or double bond; Ra represents -O-Z-Rc with Z single bond or optionally substituted alkylene and Rc represents optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; Rb represents H or F; with, if Rb is H, then Rc is not cycloalkyl when Z is a single bond and Rc is not heterocycloalkyl when Z is alkylene; X represents S, SO or SO2; A represents NH or S; W represents H, alkyl, cycloalkyl or COR with R representing cycloalkyl; alkyl; alkoxy; O-phenyl; -O-(CH2)n-phenyl with n = 1 to 4; or NR1R2 with R1 representing H or alk and R2 represents H, cycloalkyl or alkyl; or alternatively R1 and R2 form with N a ring optionally containing O, S, N and/or NH; all these radicals being optionally substituted; these products being in any isomeric form, and the salts, as medicaments, especially as MET inhibitors. |