| abstract |
The present invention relates to a cephem compound with wide antimicrobial spectrum, especially having strong anti-bacterium activity to the Gram-negative bacteria producing β -lactamase and the the pharmaceutical composition that contains thereof. The present invention provides a compound of the following formula: (wherein, X represents N, CH or C-Cl, T represents S, etc. A and G represent a lower alkylene group etc., B represents a single bond etc., D represents a single bond, -NR7-CO-, -CO-NR7-, -NR7-CO-NR7- etc., E represents an optionally substituted lower alkylene group, H represents a single bonds or an optionally substituted phenylene group, R3, R4, R5, and R6 are each independently represent a hydrogen atom, a halogen atom, and nitriles etc., the ester body or the protection body in amino group of 7th position side chain on the ring, or the pharmaceutically acceptable salts or solvates thereof. |