| abstract |
The present invention relates to the compounds having estrogenic activity selected from the group consisting of Loliolide, (4S, 6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one, (4R, 6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one and analogues thereof. The compounds of the present invention are selective estrogen receptor modulator which can selectively activate ER β , and simultaneously express high estrogenic activity which can be applied to a medical or food compositions for improving symptoms caused by estrogen deficiency. |