| abstract |
This invention relates to a compound represented by the general formula (I) (in formula, all labels are as same as the labels disclosed in this specification) its salt, its solvate and prodrugs thereof. The compound of general formula (I) is useful in the prophylaxis and/or treatment of various inflammation diseases (asthma, nephritis, neophropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis and the like), immune diseases (treatment of autoimmune diseases, rejection reaction of transplantation organs, immune inhibition, psoriasis, multiple sclerosis and the like), human immunodeficiency virus infection (acquired immunodeficiency syndromes and the like), allergosis (atopic dermatitis, hives, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteropathy and the like), inhibition of ischemic reperfusion injury, severe acute respiratory syndrome, bacterial infection associated with diabetes, metastasis and the like. |