| abstract |
The present invention provides a novel compound that shows the antitumor activity, and inhibits the interaction of the Mdm2 (murine double minute 2) protein and the p53 protein. This invention provides the imidazothiazole derivatives with various substituents, shown by following formula (l), which inhibit the interaction of the Mdm2 protein and the p53 protein, and show the antitumor activity (wherein, each of substituents in the formula (l) represented by R1, R2, R3, R4, R5, Ar1 and Ar2 is respectively synonymous with the definition in the specification). |