| abstract |
Compounds of formula (I): in which: R1 represents a phenyl or naphthyl group, or a heteroaryl group or a heterocyclic group, optionally substituted with one or more atoms or groups; Het represents a monocyclic heteroaryl group containing from 5 to 6 atoms, including from 1 to 3 heteroatoms chosen from N, O and S; X represents from 1 to 3 substituents, which are identical to or different from one another, chosen from a hydrogen, a halogen, (C1-C10)alkyl, (C1-C10)alkoxy, NRaRb, nitro and cyano, it being possible for the (C1-C10)alkyl to be optionally substituted with one or more groups chosen from a halogen, (C1-C10)alkoxy, (C1-C10)haloalkoxy, NRaRb or hydroxyl; R represents, at position 3, 5, 7 or 8 of the imidazo[1, 2-α ]pyridine, from 1 to 4 substituents, which are identical to or different from one another, chosen from a hydrogen, a halogen, (C1-C10)alkyl, halo(C1-C10)alkyl and (C1-C10)alkoxy; R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C10)alkyl group, optionally substituted with an Rf group, or an aryl group, which is optionally substituted; R4 represents a hydrogen atom, a (C1-C10)alkyl group, optionally substituted with an Rf group, or an aryl group, which is optionally substituted, in the form of a base or of an addition salt with an acid. Therapeutic use thereof and process for the synthesis thereof. |