| abstract |
The invention relates to compounds corresponding to the formula (I): in which A represents a bond, an oxygen atom or an -O-CH2-group; Ar1 represents a phenyl or heteroaryl group; Ar2 represents a phenyl, heteroaryl or heterocycloalkyl group; R1a, b, c and R2a, b, c represent a hydrogen or halogen atom or an alkyl, cycloalkyl, -alkylcycloalkyl optionally substituted by one or more halogen atoms, -OR5 (hydroxyl or alkoxy), hydroxyalkyl, alkoxyalkyl, alkoxyalkoxy, haloalkyl, -O-haloalkyl, oxo, -CO-alkyl, -CO-alkyl-NR6R7, -CO-haloalkyl, -COOR5, -alkyl-COOR5, -O-alkyl-COOR5, -SO2-alkyl, -SO2-cycloalkyl, -SO2-alkylcycloalkyl, -SO2-alkyl-OR5, -SO2-alkyl-COOR5, -SO2-alkyl-NR6R7, -SO2-haloalkyl, -alkyl-SO2-alkyl, -SO2-NR6R7, -SO2-alkyl-O-alkyl-OR5, -CONR6R7, -alkyl-CONR6R7 or -O-alkyl-NR6R7 group, or also R1a, R1b and R1c are respectively bonded to R2a, R2b and R2c and to the carbon atom which carries them and represent -O-alkyl-O-; R3 represents a hydrogen atom or an alkyl group; R4 represents a hydrogen or halogen atom or a cyano, -OR5, hydroxyalkyl, -COOR5, -NR6R7, -CONR6R7, -SO2-alkyl, -SO2-NR6R7, -NR6-COOR5, -NR6-COR5 or -CO-NR6-alkyl-OR5 group; R5, R6 and R7 represent a hydrogen atom, an alkyl group or an -alkylphenyl group; and R8 represents a hydrogen atom, an -SO2-alkyl group or a group of formula -B-Het, where B can be absent or can represent a bond, an oxygen atom or a -CO- or -SO2- (CH2)n- group with n equal to 0, 1 or 2 and where Het represents a heteroaryl or a heterocycloalkyl optionally substituted by alkyl, -SO2-alkyl and -COOR5 groups. Preparation process and therapeutic application. |