| abstract |
A novel trifluoroacetylating agent, i. e., N-trifluoroacetylmorpholine, is described. This reagent is useful in the preparation of phenyl and heterocyclic sulfonamide compounds. Methods are therefore described for preparing sulfonamide compounds of the following structure, wherein R1 and R2 are defined herein, using N-trifluoroacetylmorpholine. The sulfonamide compounds that may be prepared as described herein include 5-chloro-thiophene-2-sulfonic acid [(1S, 2R)-2-(3, 5-difluoro-phenyl)-3, 3, 3-trifluoro-1-hydroxymethyl-propyl]-amide using N-trifluoroacetylmorpholine. |