http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-200911770-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 2008-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd3ac0c4c352e4f00697aabb72adc846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e270f10d39402275f46e16b80d5c0bb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76510c15a5e52be1db3f6c70ea52216d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f81c3633fca08b08a4c2c294ecd223a |
| publicationDate | 2009-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-200911770-A |
| titleOfInvention | Piperidine/piperazine derivatives |
| abstract | The invention relates to a DGAT inhibitor of formula including any stereochemically isomeric form thereof, wherein A represents CH or N; X represents O or NRx; the dotted line represents an optional bond in case A represents a carbon atom; Y represents a direct bond; -NRx-C(=O)-; -C(=O)-NRx-; -NRx-C(=O)-Z-; -NRx-C(=O)-Z-NRy-; -NRx-C(=O)-Z-NRy-C(=O)-; -NRx-C(=O)-Z-NRy-C(=O)-O-; -NRx-C(=O)-Z-O-; -NRx-C(=O)-Z-O-C(=O)-; -NRx-C(=O)-Z-C(=O)-; -NRx-C(=O)-Z-C(=O)-O-; -NRx-C(=O)-O-Z-C(=O)-; -NRx-C(=O)-O-Z-C(=O)-O-; -NRx-C(=O)-O-Z-O-C(=O)-; -NRx-C(=O)-Z-C(=O)-NRy-; -NRx-C(=O)-Z-NRy-C(=O)-NRy-; -C(=O)-Z-; -C(=O)-Z-O-; -C(=O)-NRx-Z-; -C(=O)-NRx-Z-O-; -C(=O)-NRx-Z-C(=O)-O-; -C(=O)-NRx-Z-O-C(=O)-; -C(=O)-NRx-O-Z-; -C(=O)-NRx-Z-NRy-; -C(=O)-NRx-Z-NRy-C(=O)-; -C(=O)-NRx-Z-NRy-C(=O)-O-; R1 represents optionally substituted C1-12alkyl; C2-6alkenyl; C2-6alkynyl; C3-6cycloalkyl; aryl1; aryl1C1-6alkyl; Het1; or Het1C1-6alkyl; provided that when Y represents -NRx-C(=O)-Z-; -NRx-C(=O)-Z-NRy; -NRx-C(=O)-Z-C(=O)-NRy-; -C(=O)-Z-; -NRx-C(=O)-Z-NRy-C(=O)-NRy-; -C(=O)-NRx-Z-; -C(=O)-NRx-O-Z-; or -C(=O)-NRx-Z-NRy-; then R1 may also represent hydrogen; R2 and R3 each independently represent hydrogen; hydroxyl; carboxyl; halo; C1-6alkyl; polyhaloC1-6alkyl; C1-6alkyloxy optionally substituted with C1-4alkyloxy; C1-6alkylthio; polyhaloC1-6alkyloxy; C1-6alkyloxycarbonyl; cyano; aminocarbonyl; mono-or di(C1-4alkyl)aminocarbonyl; C1-6alkylcarbonyl; nitro; amino; mono-or di(C1-4alkyl)amino; -S(=O)p-C1-4alkyl; R4 represents hydrogen; hydroxyl; carboxyl; halo; C1-6alkyl; polyhaloC1-6alkyl; optionally substituted C1-6alkyloxy; C1-6alkylthio; polyhalo-C1-6alkyloxy; C1-6alkyloxycarbonyl wherein C1-6alkyl may optionally be substituted; cyano; C1-6alkylcarbonyl; nitro; amino; mono-or di(C1-4alkyl)amino; C1-4alkylcarbonylamino; -S(=O)p-C1-4alkyl; R6R5N-C(=O)-; R6R5N-C1-6alkyl; C3-6cycloalkyl; aryl; aryloxy; arylC1-4alkyl; aryl-C(=O)-C1-4alkyl; aryl-C(=O)-; Het; HetC1-4alkyl; Het-C(=O)-C1-4alkyl; Het-C(=O)-; Het-O-; R9 represents hydrogen, halo, C1-4alkyl, C1-4alkyl substituted with hydroxyl; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I460175-B |
| priorityDate | 2007-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 560.